abstract：:Choriocarcinoma cells grown in the presence of methotrexate (MTX) developed resistance in two ways. HCCM-derived sublines (relatively high MTX resistance) produced enhanced levels of dihydrofolate reductase (DHFR) and had impaired transport of MTX. Altered transport was the primary determinant of response in CC1-deriv...

journal_title：Gynecologic oncology

authors： Sakai K,Wake N,Fujino T,Yasuda T,Kato H,Fujimoto S,Fujinaga K

更新日期：1989-07-01 00:00:00

abstract：:A case of microinvasive squamous cell carcinoma of the vulva is reported in which regional lymph node recurrence was noted after excisional therapy. Review of the initial pathology revealed only 0.72 mm of invasion. The results of a literature survey regarding microinvasive vulvar carcinoma are discussed. ...

journal_title：Gynecologic oncology

authors： Atamdede F,Hoogerland D

更新日期：1989-07-01 00:00:00

abstract：:A total of 107 patients with carcinoma of the ovary were entered in a study combining extensive primary surgery and intensive chemotherapy. Because of evidence supporting the effectiveness of both single agent platinum (P) and the combination of cyclophosphamide and doxorubicin (CA), patients were treated with alterna...

journal_title：Gynecologic oncology

authors： Krag KJ,Canellos GP,Griffiths CT,Knapp RC,Parker LM,Welch WR,Klatt M,Andersen J

更新日期：1989-07-01 00:00:00

abstract：:A histopathologic review of synchronous primary neoplasms of the female reproductive tract is presented. During a 30-year period, 3863 patients with female genital malignancies were accessioned to the UCLA Tumor Registry: 958 had ovarian cancer, 776 endometrial cancer, 1556 cervical cancer, and 573 other gynecologic m...

journal_title：Gynecologic oncology

authors： Eisner RF,Nieberg RK,Berek JS

更新日期：1989-06-01 00:00:00

abstract：:Two-hundred and eighty-eight patients with predominately stage IIB or IIIB cervical carcinoma underwent pretreatment surgical staging including selective paraaortic lymphadenectomy (SPAL), followed by pelvic irradiation with or without paraaortic irradiation (RT). Four patients were excluded from analysis (two receive...

journal_title：Gynecologic oncology

authors： Weiser EB,Bundy BN,Hoskins WJ,Heller PB,Whittington RR,DiSaia PJ,Curry SL,Schlaerth J,Thigpen JT

更新日期：1989-06-01 00:00:00

abstract：:The CA 125 radioimmunoassay has been increasingly used to monitor the course of patients with ovarian epithelial carcinomas. The purpose of this report is to describe our experience in the use of this assay and to better define its clinical utility. Fifty-one patients had serum CA 125 follow-up during primary chemothe...

journal_title：Gynecologic oncology

authors： Podczaski E,Whitney C,Manetta A,Larson JE,Kirk J,Stevens CW,Lyter J,Mortel R

更新日期：1989-05-01 00:00:00

abstract：:One hundred fifty-five patients with cervical cancer not amenable to radical surgery underwent selective, paraaortic lymphadenectomy and exploratory laparotomy prior to the initiation of radiotherapy. Fifty-one patients underwent transperitoneal lymphadenectomy; the remainder had the procedure performed using the extr...

journal_title：Gynecologic oncology

authors： Podczaski ES,Palombo C,Manetta A,Andrews C,Larson J,DeGeest K,Mortel R

更新日期：1989-04-01 00:00:00

abstract：:A patient with three synchronous, Stage I neoplasms of the ovary, kidney, and lung, who underwent resection of all lesions at the same operative procedure, is presented. The incidence of multiple primary malignancies and the prognosis for Stage I cancers of the ovary, kidney, and lung are reviewed. ...

journal_title：Gynecologic oncology

authors： Ringler GE,Senekjian EK,Smith FL,Little AG,Clinton S,Stephens JK

更新日期：1989-04-01 00:00:00

abstract：:Five cases of primary vaginal melanoma were treated at UCLA Medical Center between 1976 and 1986. Two additional cases of melanoma arising at the junction of the vulva and vagina are presented. One of seven (13%) patients is alive, with a median time to recurrence of 7 months, and median survival of 31 months. Four of...

journal_title：Gynecologic oncology

authors： Brand E,Fu YS,Lagasse LD,Berek JS

更新日期：1989-04-01 00:00:00

abstract：:Between 1964 and 1980, 1878 patients were considered for radiotherapy at the Western Infirmary, Glasgow, of whom 1673 (91.8%) had squamous tumors and 120 (6.6%) adenocarcinomas. Of these, 1505 squamous carcinomas (92.5%) and 95 (5.8%) adenocarcinomas were treated by radical radiotherapy. The treatment given to either ...

journal_title：Gynecologic oncology

authors： Davidson SE,Symonds RP,Lamont D,Watson ER

更新日期：1989-04-01 00:00:00

abstract：:Mullerian mixed tumors, as a group, are uncommon. Only 27 cases of this tumor of the fallopian tube have been reported to date. We report the 28th case of mixed mesodermal tumor, originating in the fallopian tube. A 79-year-old woman had mistaken a bloody vaginal discharge for hematuria. Various examinations showed no...

journal_title：Gynecologic oncology

authors： Kinoshita M,Asano S,Yamashita M,Matsuda T

更新日期：1989-03-01 00:00:00

abstract：:Fifty-seven patients with malignant gestational trophoblastic disease (GTD) were treated by the Gynecologic Oncology Unit of the Tygerberg Hospital, Parowvallei, RSA, between 1977 and 1986. Treatment was primarily with triple chemotherapy (MAC) followed by citrovorum factor. The total remission rate in the 23 patients...

journal_title：Gynecologic oncology

authors： du Toit JP

更新日期：1989-03-01 00:00:00

abstract：:The therapeutic value of 131I-OC125, a radiolabeled monoclonal antibody directed against a human ovarian tumor associated antigen CA125, was examined in an ascites forming intraperitoneal human ovarian carcinoma nude mouse model. Nude mice were injected intraperitoneally with NIH:OVCAR3 cells. Twenty-one days after tu...

journal_title：Gynecologic oncology

authors： Manetta A,Satyaswaroop PG,Hamilton T,Ozols R,Mortel R

更新日期：1989-03-01 00:00:00

abstract：:Fifty patients with cervical cancer were treated with radical hysterectomy and lymphadenectomy followed by postoperative radiation therapy for high risk factors (nodal metastases, lymphvascular space invasion, close or involved margins) at the University of Alabama at Birmingham Medical Center from 1969 to 1984. Fifte...

journal_title：Gynecologic oncology

authors： Barter JF,Soong SJ,Shingleton HM,Hatch KD,Orr JW Jr

更新日期：1989-03-01 00:00:00

abstract：:Forty-two patients with malignant, mixed mesodermal tumors of the uterus were identified by retrospective chart review. Only 2 patients were premenopausal at the time of diagnosis. Six of the patients had previously received pelvic radiotherapy. Surgical/pathologic findings were inconsistent with clinical staging in 1...

journal_title：Gynecologic oncology

authors： Podczaski ES,Woomert CA,Stevens CW Jr,Manetta A,Larson JE,Zaino RJ,Mortel R

更新日期：1989-02-01 00:00:00

abstract：:Roughly one-third of patients with ataxia-telangiectasia (AT) develop malignant tumors, usually of lymphoid origin. AT patients also exhibit progeric changes. We describe three patients, between the ages of 27 and 32 years, with uterine tumors: one with a frank leiomyosarcoma and chronic T-cell leukemia, one with a mu...

journal_title：Gynecologic oncology

authors： Gatti RA,Nieberg R,Boder E

更新日期：1989-02-01 00:00:00

abstract：:Tumor specimens from 92 patients with ovarian carcinoma were analyzed for estrogen receptor (ER), progesterone receptor (PR), proliferative fraction, and ploidy. Seventy-one percent of tumors were either ER+ (greater than 5 fmole/mg protein) or PR+ (greater than 10 fmole/mg protein) with 27% of tumors overall being bo...

journal_title：Gynecologic oncology

authors： Friedlander ML,Quinn MA,Fortune D,Foo MS,Toppila M,Hudson CN,Russell P

更新日期：1989-02-01 00:00:00

abstract：:Among 713 patients followed after treatment for cancer of the uterine cervix, 48 (6.6%) had a metastasis to the bone. The rates of metastasis in each of the four clinical stages were 11/273 (4.0%) in stage I, 16/243 (6.6%) in stage II, 13/162 (8.0%) in stage III, and 8/35 (22.9%) in stage IV, respectively. The most fr...

journal_title：Gynecologic oncology

authors： Matsuyama T,Tsukamoto N,Imachi M,Nakano H

更新日期：1989-01-01 00:00:00

abstract：:Thirty-eight patients with advanced or recurrent carcinoma of the endometrium who had received no prior chemotherapy were placed on study by the Gynecologic Oncology Group. One was deemed histologically ineligible. Three patients had insufficient trials to evaluate response. Of the remaining 34 who received hexamethyl...

journal_title：Gynecologic oncology

authors： Thigpen JT,Blessing JA,Ball H,Hanjani P,Manetta A,Homesley H

更新日期：1988-11-01 00:00:00

abstract：:From January 1, 1946, through January 1, 1986, at the University of Michigan, 60 patients were treated with Stage IB (FIGO) carcinoma of the cervix with lymph node metastases. Clinical variables were examined with regard to long-term survival. Prognostically significant variables were (1) highest level of lymph node i...

journal_title：Gynecologic oncology

authors： Terada KY,Morley GW,Roberts JA

更新日期：1988-11-01 00:00:00

abstract：:The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated a...

journal_title：Gynecologic oncology

authors： Acaia B,Parazzini F,La Vecchia C,Ricciardiello O,Fedele L,Battista Candiani G

更新日期：1988-10-01 00:00:00

abstract：:The Cavitron Ultrasonic Surgical Aspirator (CUSA) can be used to fragment and aspirate tissue precisely. The CUSA was utilized as an adjunctive procedure to standard operative techniques to optimally debulk 11 women with advanced epithelial carcinoma of the ovary. No significant intraoperative or postoperative complic...

journal_title：Gynecologic oncology

authors： Deppe G,Malviya VK,Malone JM Jr

更新日期：1988-09-01 00:00:00

abstract：:In a study designed to determine the merit of preserving ovarian function and childbearing capability in women with unilateral malignant ovarian tumors, the results of radical surgery (n = 86) and conservative surgery (n = 106) were compared. The mean length of survival was slightly but not significantly shorter follo...

journal_title：Gynecologic oncology

authors： Miyazaki T,Tomoda Y,Ohta M,Kano T,Mizuno K,Sakakibara K

更新日期：1988-07-01 00:00:00

abstract：:Verrucous carcinoma (VC) of the female genital tract is a rare lesion, primarily affecting postmenopausal women. A case of VC of the vulva is reported, bringing the total number of VC of the female genital tract to 89. VC is a slowly growing, locally "pushing" tumor with a rather benign histologic appearance, and the ...

journal_title：Gynecologic oncology

authors： Andersen ES,Sorensen IM

更新日期：1988-07-01 00:00:00

abstract：:Stains for mucosubstances were performed on endometrial curetting material of normal and pathological endometrium. The study included normal proliferative and secretory endometrium, cystic and adenomatous hyperplasia, and endometrial adenocarcinoma. It was attempted to characterize the epithelial mucin in each of thes...

journal_title：Gynecologic oncology

authors： Lurie M,Elmalach I,Weill S

更新日期：1988-06-01 00:00:00

abstract：:A case of malignant pericardial effusion in a 67-year-old patient with serous ovarian cystadenocarcinoma is presented. Pericardial effusion was treated successfully with cyclophosphamide, doxorubicin, and cisplatin. The primary tumor had previously been assumed to be sensitive to this combination by using an in vivo p...

journal_title：Gynecologic oncology

authors： Mäenpää J,Taina E,Erkkola R

更新日期：1988-06-01 00:00:00

abstract：:Forty-five patients with invasive cervical squamous cell carcinoma were registered in the Tom Baker Cancer Centre from 1980 to 1985. The natural history of 22 patients (48.9%) who developed persistent or recurrent disease including 11 Stage IB, 8 Stage IIB, and 3 Stage IIIB is reported. Only one patient who had the un...

journal_title：Gynecologic oncology

authors： Stuart GC,Robertson DI,Fedorkow DM,Duggan MA,Nation JG

更新日期：1988-06-01 00:00:00

abstract：:Classification of ovarian tumors according to FIGO does not take into account involvement of spleen. A patient who appears to be the first reported case of widespread carcinoma of the ovary with involvement of the splenic parenchyma is presented. ...

journal_title：Gynecologic oncology

authors： Glezerman M,Yanai-Inbar I,Charuzi I,Katz M,Glasner M,Piura B

更新日期：1988-05-01 00:00:00

abstract：:From June 1, 1984, to May 31, 1985, 98 cases of epithelial ovarian carcinomas were assessed and followed prospectively using a new murine monoclonal antibody OC 125 which detects the antigen CA 125. Serous tumors comprised 43.7% of cases, mucinous tumors 20.4%, endometrioid tumors 16%, and other epithelial tumors 19.4...

journal_title：Gynecologic oncology

authors： Altaras MM,Goldberg GL,Levin W,Bloch B,Darge L,Smith JA

更新日期：1988-05-01 00:00:00

abstract：:While several different human papillomaviruses (HPV) have been associated with cancer of the cervix, it is yet to be determined if specific HPV types have clinical or prognostic significance. To address this question, 30 cases of invasive carcinoma (squamous carcinoma, adenosquamous carcinoma, and adenocarcinoma) with...

journal_title：Gynecologic oncology

authors： Barnes W,Delgado G,Kurman RJ,Petrilli ES,Smith DM,Ahmed S,Lorincz AT,Temple GF,Jenson AB,Lancaster WD

更新日期：1988-03-01 00:00:00

abstract：:Absorbable synthetic mesh (910-polyglactin) was used to create an intestinal sling in six patients undergoing surgical staging of pelvic malignancies prior to radiation therapy. All patients had effective compartmentalization of small intestine out of the pelvis which persisted throughout the duration of radiation the...

journal_title：Gynecologic oncology

authors： Soper JT,Clarke-Pearson DL,Creasman WT

更新日期：1988-03-01 00:00:00

abstract：:In 74 patients with advanced ovarian cancer, the value of DNA flow cytometry and morphometry was evaluated and compared with histological grading and clinical outcome. By means of both DNA flow cytometry and morphometry a clear distinction was found between a favorable group of 15 patients, with a median survival of m...

journal_title：Gynecologic oncology

authors： Rodenburg CJ,Cornelisse CJ,Hermans J,Fleuren GJ

更新日期：1988-02-01 00:00:00

abstract：:The rate of regression of the beta subunit of human chorionic gonadotropin in patients successfully treated by single-agent chemotherapy with methotrexate (MTX) for postmolar nonmetastatic gestational trophoblastic neoplasia (NMGTN) has not previously been described. In 21 patients with NMGTN treated with MTX, the rat...

journal_title：Gynecologic oncology

authors： Rotmensch J,Rosenshein NB,Block BS

更新日期：1988-01-01 00:00:00

abstract：:Over a 20-year period, 34 patients with FIGO stage II ovarian carcinoma were treated with postoperative pelvic irradiation at the University of Michigan. Complications of radiation treatment were minimal. The overall actuarial disease-free 5-year survival was 53%. This was not significantly different for substages IIA...

journal_title：Gynecologic oncology

authors： Terada KY,Morley GW,Roberts JA

更新日期：1988-01-01 00:00:00

abstract：:CA125 and CA19-9 levels were serially evaluated in blood samples from 21 patients during and after integrated surgical and chemotherapeutic treatment for ovarian carcinoma. Serial measurement of CA125 and CA19-9 correlated with clinical course of disease in 89.7 and 72.7% of instances, respectively. The decrease of se...

journal_title：Gynecologic oncology

authors： Fioretti P,Gadducci A,Ferdeghini M,Bartolini T,Bianchi R,Facchini V

更新日期：1987-11-01 00:00:00

abstract：:Open biopsy of the left scalene lymph nodes has been utilized to identify distant spread of cervical carcinoma in selected groups of patients who do not have other clinical evidence of disseminated disease. Twenty-one patients with primary cervical carcinoma and histologically proven para-aortic lymph node metastases ...

journal_title：Gynecologic oncology

authors： Burke TW,Heller PB,Hoskins WJ,Weiser EB,Nash JD,Park RC

更新日期：1987-11-01 00:00:00

abstract：:Twenty-five patients underwent adjunctive extrafascial hysterectomy 14-60 days following completion of external and intracavitary irradiation for bulky carcinoma of the uterine cervix. Review of the operative histopathology and correlation with subsequent patient outcomes suggests that morphologically persistent cance...

journal_title：Gynecologic oncology

authors： Russell AH,Burt AR,Ek M,Russell KJ,Cain JM,Greer BE,Tamimi HK,Figge DC

更新日期：1987-10-01 00:00:00

abstract：:Pelvic washings for cytologic analysis have become an accepted diagnostic procedure in the management of endometrial carcinoma. A retrospective study was performed in 163 consecutive patients with FIGO Stage I and II endometrial carcinoma to assess the significance and value of the washings. Abnormal results were obta...

journal_title：Gynecologic oncology

authors： Kennedy AW,Peterson GL,Becker SN,Nunez C,Webster KD

更新日期：1987-09-01 00:00:00

abstract：:In patients with small central recurrences following radiation therapy for cervical cancer the surgeon may have to make a judgment as to when radical hysterectomy is preferable to exenteration. During the years 1968-1984 there were 21 radical hysterectomies performed at Memorial Sloan-Kettering Cancer Center for recur...

journal_title：Gynecologic oncology

authors： Rubin SC,Hoskins WJ,Lewis JL Jr

更新日期：1987-07-01 00:00:00

abstract：:Normal and neoplastic endometrial tissues were examined immunohistochemically for chromogranin which was shown to be a specific marker for neuroendocrine cells. All 20 normal endometriums and 20 endometrial carcinomas without argyrophilia were chromogranin negative. Endometrial carcinomas with argyrophilia tested were...

journal_title：Gynecologic oncology

authors： Ueda G,Nishino T,Saito J,Abe Y,Shimizu H,Tanizawa O

更新日期：1987-06-01 00:00:00